Description

Clemastine CAS NO 108825-05-4 is a potent, selective histamine H1-receptor antagonist belonging to the ethanolamine class of antihistamines. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in blocking allergic reactions. It is primarily required by pharmaceutical manufacturers for the formulation of prescription and over-the-counter medications targeting allergic conditions such as hay fever, urticaria, and allergic rhinitis.

Application

• Pharmaceutical API: Core active ingredient in antihistamine tablets, syrups, and injectable formulations.
• Allergy Medications: Manufacture of drugs for symptomatic relief of seasonal and perennial allergic rhinitis.
• Antipruritic Agents: Used in creams and oral medications to relieve itching associated with hives (urticaria) and skin allergies.
• Veterinary Pharmaceuticals: Component in antihistamine preparations for allergic conditions in animals.
• Research & Development: Reference standard and building block in pharmacological research for studying H1-receptor activity.
• Combination Therapies: Used in fixed-dose combination drugs with decongestants or other active ingredients.

Basic Information

Product Name	Clemastine
CAS No.	108825-05-4
Molecular Formula	C21H26ClNO
Molecular Weight	343.89 g/mol
Synonyms	Meclastine; Tavegil; Tavegyl; Clemastine Fumarate (salt form); (+)-(2R)-2-[2-[(R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine; 1-Methyl-2-[2-(1-(p-chloro-α-phenylbenzyl)oxy)ethyl]pyrrolidine; 2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine; Aller-Eze; Antihist-1
EINECS	Contact for details

Quality Control

Our Clemastine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, including identification, assay, and impurity profile analysis. Certificates of Analysis (COA) documenting compliance with in-house specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.