Description

3-(Trifluoromethoxy)Phenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for introducing the unique trifluoromethoxy (OCF₃) pharmacophore into complex molecular architectures. Its value lies in enabling the synthesis of advanced intermediates with enhanced metabolic stability, lipophilicity, and bioavailability for pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for CNS drugs, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the OCF₃ group for improved pest control efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the development of fluorinated components for electronic displays and organic light-emitting diodes due to its electronic properties.
• Advanced Polymer Chemistry: Serves as a monomer or modifier for creating specialty polymers with specific chemical resistance and thermal stability.
• Cross-Coupling Reactions: A valuable substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to construct complex biaryl systems.
• Functional Material Research: Employed in academic and industrial R&D for exploring new fluorinated compounds with tailored properties.

Basic Information

Product Name	3-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	108307-56-8
Molecular Formula	C₉H₆F₃NO
Molecular Weight	201.15 g/mol
Synonyms	2-[3-(Trifluoromethoxy)phenyl]acetonitrile; (3-Trifluoromethoxyphenyl)acetonitrile; m-(Trifluoromethoxy)phenylacetonitrile; 3-(Trifluoromethoxy)benzyl cyanide; α-Cyano-3-(trifluoromethoxy)toluene; 108307-56-8; 3-Trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.