Description

n-Acetyl-Calicheamicin is a potent semi-synthetic derivative of the enediyne antibiotic calicheamicin, specifically engineered for targeted therapeutic applications. This compound is of critical importance in the development of Antibody-Drug Conjugates (ADCs), where it serves as a highly cytotoxic payload to precisely eliminate cancer cells. It is primarily required by pharmaceutical R&D teams, biotech companies, and advanced contract manufacturing organizations (CMOs) focused on next-generation oncology treatments. Its mechanism of action involves causing double-strand DNA breaks, making it a cornerstone agent in targeted cancer therapy platforms.

Application

• Antibody-Drug Conjugate (ADC) Payload: As the cytotoxic warhead in ADCs like gemtuzumab ozogamicin, targeting specific cancer cell antigens.
• Oncology Research: A key tool for studying DNA damage response pathways and mechanisms of targeted cytotoxicity in preclinical models.
• Pharmaceutical Intermediate: Used in the synthesis and development of novel targeted chemotherapeutic agents.
• Bioconjugation Chemistry: Serves as a model compound for developing new linker technologies and conjugation strategies in ADC engineering.
• Mechanistic Studies: Employed in biochemical assays to investigate enediyne-induced DNA cleavage and repair processes.

Basic Information

Product Name	n-Acetyl-Calicheamicin
CAS No.	108212-76-6
Molecular Formula	C60H84IN3O21S4
Molecular Weight	1428.41 g/mol
Synonyms	N-Acetyl-γ1I-Calicheamicin; Calicheamicin Derivative; N-Acetylcalicheamicin γ1I; CMA-676 payload; Gemtuzumab ozogamicin payload; (1S,2R,3S,4S,7S,9S,10S,12R)-12-[(2R,3S,4S,6S)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,9,10-trihydroxy-4-[(1E,3E,5E,7Z)-8-[(1S,2R)-2-hydroxy-1,2-dimethylpropyl]-7-iodo-1,3,5,7-octatetrayn-1-yl]-10-{[(2S,3S)-3-[(2-{[(2S,3S)-3-[(2-{[(2S,3S)-3-(Acetylamino)-2-hydroxy-3-methylbutanoyl]amino}acetyl)amino]-2-hydroxy-3-methylbutanoyl]amino}acetyl)amino]-2-hydroxy-3-methylbutanoyl]amino}-3,5,7,9,11,13-hexamethyl-6,14-dioxabicyclo[9.3.1]pentadeca-11,15-diene-8,15-dione
EINECS	Contact for details

Quality Control

Our n-Acetyl-Calicheamicin is produced and controlled under strict quality management systems suitable for pharmaceutical research applications. Each batch undergoes comprehensive analytical testing including HPLC purity analysis, structural confirmation (NMR, MS), and impurity profiling to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting critical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.