Description

Icomethasone 21-Propionate is a synthetic corticosteroid derivative, specifically a propionate ester of icomethasone. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing topical and systemic corticosteroid therapies for dermatological and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroid APIs.
• Anti-inflammatory Drug Research: Used in R&D for developing new treatments for eczema, psoriasis, and dermatitis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor activity and steroid metabolism.
• Veterinary Medicine: Potential application in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	Icomethasone 21-Propionate
CAS No.	107085-37-0
Molecular Formula	C26H35FO6
Molecular Weight	462.56 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-propionate; Icomethasone Propionate; 21-Propionyloxy-9α-fluoro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-propionate; Icomethasone 21-propanoate
EINECS	Contact for details

Quality Control

Our Icomethasone 21-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-grade pharmaceutical intermediate standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.