Description

Benzonitrile, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)- (9Ci) is a high-value trifluoromethylated benzonitrile derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring both a nitrile and a trifluoromethyl-substituted hydroxyethyl group, enables precise molecular modifications essential for developing compounds with enhanced biological activity and physical properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in CNS and metabolic disease drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Advanced Material Science: Building block for functional polymers and specialty chemicals requiring specific optical or electronic properties.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring novel fluorination chemistry and asymmetric synthesis pathways.

Basic Information

Product Name	Benzonitrile, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)- (9Ci)
CAS No.	107018-37-1
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	4-(2,2,2-Trifluoro-1-hydroxyethyl)benzonitrile; 1-(4-Cyanophenyl)-2,2,2-trifluoroethanol; α-(Trifluoromethyl)-4-cyanobenzyl alcohol; p-Cyanotrifluoromethylbenzyl alcohol; 4-(1-Hydroxy-2,2,2-trifluoroethyl)benzonitrile; 2,2,2-Trifluoro-1-(4-cyanophenyl)ethanol; 4-Cyano-α-(trifluoromethyl)benzyl alcohol
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released against comprehensive specifications, including chiral purity and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, enantiomeric excess, and related substances. Our quality system supports cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.