Description

4'-Amino-3'-Hydroxydoxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest in pharmaceutical research and development due to its potential for altered biological activity and reduced cardiotoxicity compared to the parent drug. It serves as a critical intermediate and reference standard for researchers in oncology, medicinal chemistry, and pharmacology who are developing next-generation chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel anthracycline-based anticancer drugs and prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to understand the impact of amino and hydroxyl substitutions on efficacy and toxicity profiles.
• Biochemical Research: Employed as a reference standard in assays studying DNA intercalation, topoisomerase II inhibition, and cellular apoptosis mechanisms.
• Anticancer Agent Development: Investigated for the development of targeted therapies and drug conjugates with improved tumor selectivity.
• Analytical Standard: Serves as a high-purity calibrant for quality control and analytical method development (HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	4'-Amino-3'-Hydroxydoxorubicin
CAS No.	106492-47-1
Molecular Formula	C₂₇H₂₉NO₁₁
Molecular Weight	543.52 g/mol
Synonyms	4'-Amino-3'-hydroxydoxorubicin; 3'-Hydroxy-4'-aminodoxorubicin; 4'-Amino-3'-hydroxy-14-hydroxydaunomycin; Doxorubicin, 4'-amino-3'-hydroxy-; AD 198 (related analog); 4'-Amino-3'-hydroxyadriamycin
EINECS	Contact for details

Quality Control

Our 4'-Amino-3'-Hydroxydoxorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.