Description

Azinomycin B is a potent, naturally occurring antitumor antibiotic belonging to the azinomycin family, characterized by its unique aziridino[1,2-a]pyrrolidine ring system. This compound is of significant interest in pharmaceutical research and development due to its ability to form interstrand cross-links with DNA, making it a valuable tool for studying DNA damage and repair mechanisms. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in oncology research, anticancer drug discovery, and molecular biology studies.

Application

• Anticancer Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel oncology therapeutics.
• Biochemical Mechanism Studies: Used as a molecular probe to investigate DNA alkylation, interstrand cross-linking, and subsequent cellular apoptosis pathways.
• Pharmaceutical Development: Acts as a lead compound or intermediate in the synthesis and development of next-generation chemotherapeutic agents.
• Academic Research: Employed in university and institutional labs for studying the structure-activity relationships (SAR) of complex natural products.
• Quality Control & Analytical Standards: Provides a high-purity standard for HPLC, LC-MS, and NMR analysis in pharmaceutical quality assurance laboratories.

Basic Information

Product Name	Azinomycin B
CAS No.	106486-76-4
Molecular Formula	C30H40N4O9
Molecular Weight	600.66 g/mol
Synonyms	Carzinophilin A; Azinomycin A analog; KF-21355; Antibiotic KF 21355; [1S-(1R*,2S*,10S*,11R*,12S*,13R*)]-1,2,10,11,12,13-Hexahydro-2,13-dihydroxy-10-[(1S)-1-hydroxyethyl]-1,6,12-trimethyl-8-[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-5,16-dioxa-3,7,15,19-tetraazatetracyclo[12.7.0.02,11.04,9]henicosa-4,6,8,14,17-pentaene-14,18-dione
EINECS	Contact for details

Quality Control

Our Azinomycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for research chemicals and can provide material for use under GLP (Good Laboratory Practice) conditions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.