Description

2-Fluoro-4-Cyanobenzyl Bromide is a versatile and high-value aromatic building block, essential for constructing complex molecular architectures in advanced chemical synthesis. Its core value lies in the strategic combination of a reactive benzyl bromide handle and a cyano group, enabling sequential functionalization critical for pharmaceutical and materials science research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorine and cyano groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Monomer: Employed in the synthesis of functionalized polymers and liquid crystals, where the aromatic core and cyano group influence material properties.
• Fluorinated Building Block: The fluorine atom makes it a valuable synthon for introducing fluorination into target molecules, a common strategy to modulate lipophilicity and bioavailability.
• Cross-Coupling Substrate: The benzyl bromide moiety allows for efficient participation in various cross-coupling reactions (e.g., Suzuki, Negishi) for carbon-carbon bond formation.

Basic Information

Product Name	2-Fluoro-4-Cyanobenzyl Bromide
CAS No.	105942-09-4
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-4-cyanobenzene; 2-Fluoro-4-cyanobenzyl bromide; 4-Cyano-2-fluorobenzyl bromide; (2-Fluoro-4-cyanophenyl)methyl bromide; α-Bromo-2-fluoro-4-cyanotoluene; 2-Fluoro-4-cyanobenzylbromide; 2-Fluoro-4-cyanobenzyl bromide, 97%; 105942-09-4
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Cyanobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.