Description

4-Bromo-2-Fluorobenzonitrile is a versatile halogenated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on a benzonitrile core, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where specific halogen interactions are required.
• Fluorinated Building Block: Integral for introducing the 2-fluorobenzonitrile motif into larger molecular architectures in medicinal chemistry programs.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	4-Bromo-2-Fluorobenzonitrile
CAS No.	105942-08-3
Molecular Formula	C7H3BrFN
Molecular Weight	200.01 g/mol
Synonyms	2-Fluoro-4-bromobenzonitrile; 4-Bromo-2-fluorobenzene carbonitrile; 4-Bromo-2-fluorophenyl cyanide; Benzonitrile, 4-bromo-2-fluoro-; 2-Fluoro-4-bromobenzene nitrile; 4-Bromo-2-fluoro benzonitrile; 105942-08-3; 4-Br-2-F-C6H3CN
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68°C - 72°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.