Description

10'-o-Demethylstreptonigrin is a structurally complex, bioactive natural product derivative. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity profile. It serves as a critical intermediate and reference standard for researchers in oncology and antibiotic discovery, particularly in the study of novel therapeutic mechanisms.

Application

• Pharmaceutical Research Intermediate: A key building block in the synthesis and structural modification of novel anticancer and antimicrobial agents.
• Biochemical Reference Standard: Used for analytical method development, calibration, and quality control in laboratories studying streptonigrin analogs.
• Mechanism of Action Studies: Employed in preclinical research to investigate DNA intercalation, topoisomerase inhibition, and the induction of oxidative stress in cellular models.
• Academic & Institutional Research: A vital tool for universities and research institutes exploring natural product chemistry and medicinal chemistry.
• Bioactivity Screening: Used as a reference compound in high-throughput screening assays to identify new drug candidates with similar or enhanced activity profiles.

Basic Information

Product Name	10'-o-Demethylstreptonigrin
CAS No.	105933-56-0
Molecular Formula	C25H21N3O8
Molecular Weight	491.45 g/mol
Synonyms	10'-O-Demethylstreptonigrin; 10'-Desmethylstreptonigrin; NSC 353451; Streptonigrin, 10'-demethyl-; Antibiotic BA 180265 A; BA 180265 A
EINECS	Contact for details

Quality Control

Our 10'-o-Demethylstreptonigrin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications of your material.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Dark red to brown powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.