Description

Apafant is a high-purity, synthetic chemical compound widely recognized for its role as a potent and selective platelet-activating factor (PAF) receptor antagonist. This specificity makes it a valuable research tool and a key intermediate in the development of therapeutic agents targeting inflammatory pathways. It is essential for pharmaceutical R&D, particularly in studies related to asthma, allergic responses, and cardiovascular research. The compound is supplied to meet the stringent requirements of global research institutions and advanced manufacturing facilities.

Application

• Pharmaceutical Research & Development: As a critical reference standard and intermediate in the synthesis of novel PAF antagonist drugs.
• Biochemical Assays: Used in in vitro and in vivo studies to investigate the role of PAF in inflammatory and allergic diseases.
• Mechanism of Action Studies: Essential for elucidating signal transduction pathways and receptor binding kinetics in cellular models.
• Preclinical Development: Serves as a key active pharmaceutical ingredient (API) intermediate for formulation and toxicology studies.
• Academic Research: Utilized in university and institutional labs for cardiovascular and immunological research projects.

Basic Information

Product Name	Apafant
CAS No.	105219-56-5
Molecular Formula	C26H29N3O4
Molecular Weight	447.53 g/mol
Synonyms	WEB 2086; Apafant; 4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanoyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; (±)-Apafant; 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-1-oxopropyl]-; WEB2086
EINECS	Contact for details

Quality Control

Our Apafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a dry environment and opened under conditions of low humidity to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.