Description

3,5-Difluoro-4-Methoxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both methoxy and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where its structure aids in tuning electronic properties.
• Functional Polymer Monomer: Employed in the creation of specialty polymers with specific dielectric, thermal, or surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl systems.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	3,5-Difluoro-4-Methoxybenzonitrile
CAS No.	104197-15-1
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	4-Methoxy-3,5-difluorobenzonitrile; 3,5-Difluoro-4-methoxybenzonitrile; Benzonitrile, 3,5-difluoro-4-methoxy-; 3,5-Difluoro-p-anisonitrile; 3,5-Difluoro-4-methoxy-phenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-Methoxybenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.