Description

Brefonalol CAS NO 104051-20-9 is a specialized organic compound belonging to the class of β-adrenergic receptor antagonists, commonly known as β-blockers. This high-purity intermediate is critical for the research and development of novel cardiovascular and ophthalmic pharmaceutical agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced β-blocker drug candidates for treating hypertension, angina, and arrhythmias.
• Research Chemical: Used in biochemical and pharmacological studies to investigate adrenergic receptor mechanisms and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Serves as a precursor for the preparation of more complex, optically active molecules in medicinal chemistry.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	Brefonalol
CAS No.	104051-20-9
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	Brefonalol; 1-(tert-Butylamino)-3-[(5,6,7,8-tetrahydro-6-methyl-1,8-naphthyridin-2-yl)oxy]propan-2-ol; (RS)-Brefonalol; (±)-Brefonalol; Brefonalolum; UNII-8I3H5WQ0FE
EINECS	Contact for details

Quality Control

Our Brefonalol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Chiral Purity	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.