Description

7-o-(2,6-Dideoxy-2-Fluorotalopyranosyl)Daunomycinone is a fluorinated anthracycline glycoside derivative, representing a key synthetic intermediate in advanced pharmaceutical research. This compound is engineered to enhance the therapeutic profile and reduce the cardiotoxicity associated with traditional anthracycline-based chemotherapeutics. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology drug discovery and the synthesis of novel antitumor agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of next-generation anthracycline anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action against various cancer cell lines.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the daunomycinone scaffold to improve efficacy and safety profiles.
• Preclinical Development: Serves as a precursor in the development and scale-up of experimental chemotherapeutic candidates.
• Academic Research: Employed in university and institutional labs for studying DNA intercalation and topoisomerase II inhibition.
• Process Chemistry: Used in route development and optimization for the commercial manufacturing of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7-o-(2,6-Dideoxy-2-Fluorotalopyranosyl)Daunomycinone
CAS No.	103946-11-8
Molecular Formula	C27H28FNO9
Molecular Weight	529.51 g/mol
Synonyms	2'-Fluorodaunorubicin aglycone; 7-O-(2,6-Dideoxy-2-fluoro-α-L-talopyranosyl)daunomycinone; 2'-Fluoro-2',6'-dideoxy-α-L-talopyranosyl daunomycinone; Daunomycinone, 7-O-(2,6-dideoxy-2-fluoro-α-L-talopyranosyl)-; 2'-Fluoro-2',6'-dideoxytalopyranosyl daunomycinone; 103946-11-8; 7-O-(2,6-Dideoxy-2-fluoro-α-L-talosyl)daunomycinone
EINECS	Contact for details

Quality Control

Our 7-o-(2,6-Dideoxy-2-Fluorotalopyranosyl)Daunomycinone is produced under strict quality management systems suitable for research and development use. Each batch undergoes comprehensive analytical characterization, including HPLC for purity verification and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.