Description

3-Chloro-4,5-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors, antiviral agents, and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups contribute to metabolic stability and binding affinity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies, leveraging its polarity and molecular shape.
• Organic Electronics: Employed in the synthesis of electron-deficient units for organic semiconductors, OLEDs, and other electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination to introduce the substituted phenyl moiety.
• Chemical Research & Development: A valuable building block in medicinal chemistry and material science research for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	3-Chloro-4,5-Difluorobenzonitrile
CAS No.	103879-29-4
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	3-Chloro-4,5-difluorobenzonitrile; 4,5-Difluoro-3-chlorobenzonitrile; Benzonitrile, 3-chloro-4,5-difluoro-; 3-Chloro-4,5-difluorophenyl cyanide; 103879-29-4; 2-Chloro-4,5-difluorobenzonitrile (isomer); 3-Cl-4,5-F2-PhCN
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for sensitive synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring traceability and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.