Description

n-(2-Hydroxyethyl)Doxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is significant for its potential to modulate the pharmacokinetic profile and therapeutic index of the parent drug, offering avenues for improved drug delivery and reduced systemic toxicity. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and medicinal chemistry for the synthesis of novel prodrugs and targeted cancer therapeutics.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel doxorubicin prodrugs and conjugates.
• Oncology Research: Used in preclinical studies to investigate structure-activity relationships (SAR) and develop new anthracycline-based chemotherapeutic agents.
• Drug Delivery Systems: Incorporated into the design of antibody-drug conjugates (ADCs), polymer-drug conjugates, and liposomal formulations for targeted cancer therapy.
• Medicinal Chemistry: Serves as a model compound for studying chemical modifications aimed at overcoming multidrug resistance (MDR) or reducing cardiotoxicity.
• Bioconjugation Studies: The hydroxyethyl group provides a handle for further chemical linkage to targeting moieties, peptides, or other functional molecules.

Basic Information

Product Name	n-(2-Hydroxyethyl)Doxorubicin
CAS No.	103851-20-3
Molecular Formula	C₂₉H₃₃NO₁₃
Molecular Weight	603.57 g/mol
Synonyms	2'-Hydroxyethyldoxorubicin; Doxorubicin 2'-hydroxyethyl derivative; 14-O-[(2-Hydroxyethyl)amino]doxorubicin; AD 198 (related derivative); N-(2-Hydroxyethyl)-14-O-doxorubicin; Hydroxyethyl doxorubicin; Doxorubicin hydroxyethylamide
EINECS	Contact for details

Quality Control

Our n-(2-Hydroxyethyl)Doxorubicin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	90.0% - 110.0% of labeled amount
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.