Description

2,4-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. This high-purity intermediate is critical for introducing the 2,4-difluorobenzene moiety into complex molecular architectures, enabling precise control over the physical and biological properties of the final product. It is primarily sought after by research and development laboratories and production facilities in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer Modification: Employed to create specialty polymers and resins with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions to construct complex heterocycles and functionalized aromatics.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.

Basic Information

Product Name	2,4-Difluorobenzonitrile
CAS No.	103496-86-2
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,4-Difluorobenzene carbonitrile; 2,4-Difluorophenyl cyanide; 2,4-Difluorobenzonitrile; 2,4-DFBN; Benzonitrile, 2,4-difluoro-; 2,4-Difluorobenzyl nitrile (common misnomer); 1-Cyano-2,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.