Description

3,4-Difluoro-5-Nitrobenzotrifluoride is a high-value fluorinated aromatic building block characterized by its nitro and trifluoromethyl substituents. This compound is essential for the synthesis of advanced agrochemicals and pharmaceuticals, where its unique substitution pattern enables the introduction of critical fluorine atoms and functional handles. It is primarily sought by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and electronic materials requiring fluorinated aromatic units.
• Organic Synthesis Building Block: The nitro group provides a versatile site for further functionalization (e.g., reduction to an amine), enabling diverse chemical transformations in complex molecule assembly.
• Research & Development: Critical for medicinal chemistry programs exploring structure-activity relationships (SAR) in drug discovery.

Basic Information

Product Name	3,4-Difluoro-5-Nitrobenzotrifluoride
CAS No.	101646-01-9
Molecular Formula	C7H2F5NO2
Molecular Weight	227.09 g/mol
Synonyms	1,2-Difluoro-3-nitro-5-(trifluoromethyl)benzene; 3,4-Difluoro-5-nitrobenzotrifluoride; 5-Nitro-3,4-difluorobenzotrifluoride; 2,3-Difluoro-6-nitro-alpha,alpha,α-trifluorotoluene; Benzene, 1,2-difluoro-3-nitro-5-(trifluoromethyl)-; 3,4-Difluoro-5-nitro-alpha,alpha,α-trifluorotoluene; 3,4-Difluoro-5-nitrobenzotrifluoride (DFNTF)
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.