Description

Arotinolol Hydrochloride is a potent, non-selective β-adrenergic receptor antagonist (β-blocker) with intrinsic sympathomimetic activity. This compound is a key active pharmaceutical ingredient (API) valued for its cardiovascular applications, particularly in the management of hypertension and angina pectoris. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications. The product is supplied under stringent quality controls to ensure consistency and efficacy for its intended uses.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of antihypertensive drugs.
• Core component in the manufacture of pharmaceutical preparations for the treatment of angina pectoris.
• Reference standard for analytical method development and validation in quality control laboratories.
• Research chemical for pharmacological studies on β-adrenergic receptor mechanisms.
• Starting material or intermediate in the synthesis of novel cardiovascular drug candidates.
• Used in clinical research and pre-clinical trials for cardiovascular disease models.

Basic Information

Product Name	Arotinolol Hydrochloride
CAS No.	101540-26-5
Molecular Formula	C15H24N2O3S • HCl
Molecular Weight	356.89 g/mol
Synonyms	5-[2-[(3-tert-Butylamino-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide hydrochloride; Almarl (as hydrochloride salt); Arotinolol HCl; (RS)-5-[2-[[3-(1,1-Dimethylethyl)amino-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide hydrochloride; (±)-Arotinolol Hydrochloride
EINECS	Contact for details

Quality Control

Our Arotinolol Hydrochloride is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, purity, and impurity profiles. We adhere to current Good Manufacturing Practices (cGMP) to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.