Description

Desloratadine is a potent, long-acting, and selective histamine H1-receptor antagonist. This active pharmaceutical ingredient (API) is the primary active metabolite of loratadine, offering a high degree of efficacy in managing allergic conditions. It is essential for pharmaceutical manufacturers developing non-sedating antihistamine medications. The compound is identified by CAS NO 100643-71-8.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter (OTC) antihistamine tablets, orally disintegrating tablets (ODTs), and syrups.
• Allergy Treatment: Formulated for the symptomatic relief of allergic rhinitis (seasonal and perennial), including sneezing, rhinorrhea, and itchy nose/palate.
• Chronic Idiopathic Urticaria: Used in medications for the treatment of skin manifestations of hives, including reduction of pruritus and wheal count.
• Combination Therapies: Can be formulated in combination with other APIs, such as pseudoephedrine, for comprehensive allergy and congestion relief.
• Generic Drug Manufacturing: A critical component for companies producing bioequivalent generic versions of branded desloratadine products.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for managing allergic reactions in animals.

Basic Information

Product Name	Desloratadine
CAS No.	100643-71-8
Molecular Formula	C19H19ClN2
Molecular Weight	310.82 g/mol
Synonyms	8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Descarboethoxyloratadine; SCH 34117; Clarinex® (Brand Name); Aerius® (Brand Name); Azomyr® (Brand Name); Desloratadin; Dexchlorpheniramine Maleate (not to be confused with)
EINECS	Contact for details

Quality Control

Our Desloratadine is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopeial standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters including assay, related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.