Description

Pregn-4-Ene-3,20-Dione, 17,21-Bis(1-Oxopropoxy)- CAS NO 19608-30-1 is a high-purity steroid derivative, specifically a diester of hydrocortisone. This compound is a critical advanced intermediate in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is essential for manufacturers requiring a reliable and consistent building block for producing potent corticosteroids and other specialized therapeutic agents. The material is primarily utilized by the pharmaceutical and life sciences research sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the manufacturing of steroid-based APIs for anti-inflammatory and immunosuppressive medications.
• Research & Development: Serves as a standard or starting material in medicinal chemistry for developing new steroid analogues.
• Biochemical Research: Used in studies investigating steroid hormone metabolism, receptor binding, and enzymatic conversion pathways.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Pregn-4-Ene-3,20-Dione, 17,21-Bis(1-Oxopropoxy)-
CAS No.	19608-30-1
Molecular Formula	C27H38O7
Molecular Weight	474.59 g/mol
Synonyms	Hydrocortisone 17,21-Dipropionate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17,21-dipropionate; Cortisol 17,21-dipropionate; NSC 47432; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 17,21-dipropionate (related); Hydrocortisone Dipropionate; 17,21-Bis(1-oxopropoxy)pregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregn-4-Ene-3,20-Dione, 17,21-Bis(1-Oxopropoxy)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.