Description

n-Desmethylpheniramine is a key pharmaceutical intermediate and metabolite of the antihistamine pheniramine. This compound is of significant value in analytical chemistry and pharmaceutical development for method validation and metabolic pathway studies. It is primarily required by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in drug metabolism and pharmacokinetics (DMPK) research, quality control, and the development of novel antihistamine therapies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of pheniramine and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Studies: Critical for in-vitro and in-vivo DMPK studies to understand the biotransformation, clearance, and activity of pheniramine-based drugs.
• Analytical Method Development: Serves as a pure standard for developing and validating HPLC, LC-MS/MS, and GC-MS methods in compliance with ICH and FDA guidelines.
• Impurity Profiling: Employed to identify, characterize, and control desmethyl-related impurities in active pharmaceutical ingredient (API) batches of pheniramine.
• Clinical Research: Used in studies investigating individual variation in drug metabolism and the pharmacological activity of pheniramine metabolites.
• Forensic Toxicology: Aids in the precise identification and quantification of pheniramine and its breakdown products in forensic samples.

Basic Information

Product Name	n-Desmethylpheniramine
CAS No.	19428-44-5
Molecular Formula	C15H19N3
Molecular Weight	241.34 g/mol
Synonyms	Desmethylpheniramine; N-Desmethylpheniramine; Monodesmethylpheniramine; Pheniramine Impurity C; Pheniramine N-Desmethyl Metabolite; 2-[α-(2-Dimethylaminoethyl)benzyl]pyridine; 2-[α-(2-Methylaminoethyl)benzyl]pyridine; Avil Metabolite
EINECS	Contact for details

Quality Control

Our n-Desmethylpheniramine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity assay by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications suitable for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.