Description

Actinomycin V CAS NO 18865-48-0 is a potent chromopeptide antibiotic belonging to the actinomycin family, known for its characteristic phenoxazone chromophore. This compound is of significant value in biochemical and pharmaceutical research due to its high-affinity binding to double-stranded DNA, which inhibits transcription. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in oncology research, molecular biology studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific inhibitor of DNA-dependent RNA synthesis to study transcription mechanisms and gene expression.
• Oncology Research: Serves as a reference standard and investigative tool in cancer research, particularly for studying apoptosis and drug resistance.
• Antibiotic Studies: Employed in microbiological research to investigate the activity and biosynthesis of peptide antibiotics.
• Pharmaceutical Development: Acts as a key intermediate or reference compound in the development and quality control of antitumor pharmaceuticals.
• Molecular Biology: Utilized in laboratory protocols to understand protein-nucleic acid interactions and chromatin structure.
• Cell Biology: Applied in cell culture studies to induce and analyze cellular stress responses and checkpoint activation.

Basic Information

Product Name	Actinomycin V
CAS No.	18865-48-0
Molecular Formula	C62H86N12O16
Molecular Weight	1263.42 g/mol
Synonyms	Actinomycin V; Actinomycin C3; Actinomycin IV; Actinomycin D analog; NSC 310305; Antibiotic X 45; 2-Amino-N,N'-bis[(6S,9R,18S)-6,9,18-tris(2-amino-2-oxoethyl)-15-benzyl-11-(1-methyl-2-oxopropyl)-5,8,11,14,17-pentaoxo-1-phenyl-2,7,10,13,16-pentaazaoctadecan-4-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide
EINECS	Contact for details

Quality Control

Our Actinomycin V is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere to minimize oxidation. The product is light-sensitive and easily oxidized; prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.