Description

Actinomycin I From Streptomycesantibioti Cus CAS NO 18865-46-8 is a potent antibiotic compound belonging to the actinomycin family, originally isolated from *Streptomyces* species. Its primary value lies in its ability to intercalate into DNA, inhibiting transcription, which makes it a critical tool for biochemical research and a reference standard in pharmaceutical development. This product is essential for researchers and quality control laboratories in the life sciences, biotechnology, and pharmaceutical sectors who require high-purity, well-characterized bioactive compounds for molecular biology studies, cytotoxicity assays, and antibiotic mechanism research.

Application

• Biochemical Research: Used as a potent inhibitor of DNA-dependent RNA synthesis to study transcription mechanisms and gene expression.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in antibiotic production and research.
• Anticancer & Cytotoxicity Studies: Employed in vitro to investigate its effects on cancer cell lines and to understand the mechanisms of apoptosis.
• Microbiological Research: Acts as a model compound for studying the activity and resistance mechanisms of actinomycin-class antibiotics.
• Molecular Biology Reagent: Utilized in experiments to halt transcription, allowing for the analysis of mRNA stability and half-life.

Basic Information

Product Name	Actinomycin I From Streptomycesantibioti Cus
CAS No.	18865-46-8
Molecular Formula	C62H86N12O16
Molecular Weight	1271.42 g/mol
Synonyms	Actinomycin I; Actinomycin C1; Dactinomycin (related compound); Actinomycin IV; Actinomycin AIV; NSC 19880; Antibiotic from *Streptomyces antibioticus*; 2-Amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid derivative
EINECS	Contact for details

Quality Control

Our Actinomycin I is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general research-grade standards, specifications can be aligned with specific pharmacopeial requirements (e.g., USP reference standards) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.