Description

6β-Methylprednisolone CAS NO 18462-27-6 is a potent synthetic glucocorticoid, a key intermediate in the synthesis of advanced steroidal pharmaceuticals. Its primary commercial value lies in its critical role as a precursor for manufacturing high-potency anti-inflammatory and immunosuppressive medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing corticosteroid-based therapies, including injectable formulations and topical treatments.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of methylprednisolone and its derivatives, such as methylprednisolone acetate and methylprednisolone sodium succinate.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor in the production of finished corticosteroid APIs for anti-inflammatory and immunosuppressive drugs.
• Research & Development: Utilized in pharmaceutical R&D for studying glucocorticoid receptor activity and developing new steroidal compounds with modified therapeutic profiles.
• Veterinary Medicine: Applied in the formulation of anti-inflammatory treatments for animals.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC and other chromatographic methods.

Basic Information

Product Name	6β-Methylprednisolone
CAS No.	18462-27-6
Molecular Formula	C₂₂H₃₀O₅
Molecular Weight	374.47 g/mol
Synonyms	6β-Methylprednisolone; 6β-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 6β-Methyl-δ1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 6β-Methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione; 6-β-Methylprednisolone; NSC 19993; 6β-Methylprednisolon; Medrate
EINECS	Contact for details

Quality Control

Our 6β-Methylprednisolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and specific tests for related substances and residual solvents, ensuring it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, and we can support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards (USP/EP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.