Description

Mithramycin A CAS NO 18378-89-7 is a potent aureolic acid-type antibiotic and antineoplastic agent isolated from *Streptomyces* species. This compound is a critical research-grade biochemical for studying transcriptional regulation and chromatin dynamics, primarily through its selective inhibition of Sp1-family transcription factors. It is essential for researchers and developers in the fields of oncology research, molecular biology, and pharmaceutical development, serving as a key tool compound for investigating cancer cell proliferation and gene expression pathways.

Application

• Oncology & Cancer Research: Used as a research tool to study mechanisms of apoptosis and to inhibit the growth of various cancer cell lines, particularly in studies of osteosarcoma and testicular cancer.
• Molecular Biology & Biochemistry: Employed to inhibit specific transcription factors (e.g., Sp1), making it invaluable for chromatin research and studies on gene expression regulation.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing and regulatory testing.
• Biochemical Pathway Analysis: A key reagent for dissecting signaling pathways involved in cell differentiation and proliferation in academic and industrial R&D settings.
• Antibiotic Research: Studied for its antimicrobial properties against Gram-positive bacteria, contributing to research on novel antibiotic mechanisms.

Basic Information

Product Name	Mithramycin A
CAS No.	18378-89-7
Molecular Formula	C52H76O24
Molecular Weight	1085.15 g/mol
Synonyms	Plicamycin; Aureolic Acid; Mithracin; LA 7017; Mitramycin; NSC-24559; Antibiotic LA 7017
EINECS	Contact for details

Quality Control

Our Mithramycin A is manufactured and tested under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general reagent-grade standards, specifications can be aligned with specific research or analytical requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider desiccation and maintaining an inert atmosphere (e.g., argon or nitrogen) to preserve stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.