Description

n-Methylmitomycin A is a potent semisynthetic derivative of the mitomycin family of antitumor antibiotics, known for its enhanced chemical stability and biological activity profile. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its mechanism of action involving DNA alkylation and cross-linking. It serves as a critical intermediate and reference standard for researchers in oncology, medicinal chemistry, and biochemistry, enabling the study of novel cancer therapeutics and targeted drug delivery systems.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel, more stable mitomycin-based chemotherapeutic agents.
• Oncology Studies: Used as a biochemical tool and reference standard to investigate mechanisms of DNA damage, cell cycle arrest, and apoptosis in cancer cell lines.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at improving efficacy and reducing side effects of anticancer drugs.
• Bioconjugation & Drug Delivery: Employed in the development of antibody-drug conjugates (ADCs) and other targeted therapies due to its potent cytotoxic payload properties.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research into bioreductive activation and hypoxia-selective cytotoxicity.
• Quality Control & Analytical Standards: Acts as a high-purity certified reference material (CRM) for HPLC, LC-MS, and NMR analysis in pharmaceutical quality assurance laboratories.

Basic Information

Product Name	n-Methylmitomycin A
CAS No.	18209-14-8
Molecular Formula	C16H19N3O5
Molecular Weight	333.34 g/mol
Synonyms	7-(Aminomethyl)-9a-methoxy-4-methyl-1,2,9,9a-tetrahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; N-Methylmitomycin A; Mitomycin A, N-methyl-; 9a-Methoxy-7-(methylamino)mitosane; Antibiotic MA 144M1 (methylated derivative); 7-N-Methylmitomycin A
EINECS	Contact for details

Quality Control

Our n-Methylmitomycin A is manufactured under strict quality systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for handling potent active pharmaceutical ingredients (APIs) and high-potency compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its sensitivity to light and oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry, cool, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Blue to purple crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.