Description

(20R)-11β,17-Dihydroxy-20,21-[Isopropylidenebisoxy]Pregna-1,4-Dien-3-One is a high-purity synthetic steroid derivative, recognized for its role as a key pharmaceutical intermediate. Its value lies in its precise stereochemistry and functional groups, which are critical for the synthesis of advanced corticosteroid APIs. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries, particularly those developing anti-inflammatory and immunosuppressive therapies. CAS number 18089-32-2.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Research: Used in the research and development of novel glucocorticoid receptor agonists for treating inflammatory conditions.
• Immunosuppressant Synthesis: Serves as a precursor in the manufacture of drugs designed to modulate immune system responses.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in process development and scale-up activities for optimizing synthetic routes to steroid-based therapeutics.
• Biochemical Research: Applied in academic and industrial research to study steroid hormone action and receptor binding mechanisms.

Basic Information

Product Name	(20R)-11β,17-Dihydroxy-20,21-[Isopropylidenebisoxy]Pregna-1,4-Dien-3-One
CAS No.	18089-32-2
Molecular Formula	C24H32O5
Molecular Weight	400.51 g/mol
Synonyms	11β,17,21-Trihydroxy-20,21-(isopropylidenedioxy)pregna-1,4-dien-3-one; 11β,17-Dihydroxy-20,21-(isopropylidenedioxy)pregna-1,4-dien-3-one; 11β,17α,21-Trihydroxy-20,21-(isopropylidenedioxy)-1,4-pregnadien-3-one; 20,21-Acetonide of Prednisolone; Prednisolone 20,21-Acetonide; 11β-Hydroxyprednisolone Acetonide; (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione cyclic 20,21-acetal with acetone
EINECS	Contact for details

Quality Control

Our (20R)-11β,17-Dihydroxy-20,21-[Isopropylidenebisoxy]Pregna-1,4-Dien-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.