Description

4-Bromo-2,3,5,6-Tetrafluorobenzonitrile is a high-value, multi-functional fluorinated aromatic building block. Its unique structure, combining bromine, fluorine, and nitrile substituents, makes it a critical intermediate for synthesizing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable fluorination chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, stability, and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart enhanced chemical resistance, lower dielectric constants, and improved weatherability.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D for exploring new fluorination methodologies and constructing novel aromatic systems.

Basic Information

Product Name	4-Bromo-2,3,5,6-Tetrafluorobenzonitrile
CAS No.	17823-40-4
Molecular Formula	C7BrF4N
Molecular Weight	245.98 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-bromobenzonitrile; Benzonitrile, 4-bromo-2,3,5,6-tetrafluoro-; 4-Bromo-2,3,5,6-tetrafluorobenzene carbonitrile; 4-Bromo-perfluorobenzonitrile; TFB-Br (abbreviation); 17823-40-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3,5,6-Tetrafluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.