Description

(7R)-8-Ethyl-7,8,9,10-Tetrahydro-1,6,7,8α,11-Pentahydroxy-5,12-Naphthacenedione CAS NO 17514-35-1 is a complex, multi-hydroxylated naphthacenedione derivative, a chemical class known for its significant biological and chemical activity. This compound matters as a high-purity synthetic intermediate or reference standard for advanced research and development in life sciences. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, antibiotic development, and chemical synthesis. Its precise stereochemistry and functional groups make it a valuable building block for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or probe in studies investigating DNA intercalation, topoisomerase inhibition, and oxidative stress pathways.
• Antibiotic Development: Acts as a core structural motif for developing new classes of antibiotics, leveraging the biological activity of the naphthacenedione scaffold.
• Academic & Contract Research: Employed in university and CRO laboratories for mechanistic studies, structure-activity relationship (SAR) analysis, and novel compound library synthesis.
• High-Purity Analytical Standard: Provides a certified reference material for quality control and analytical method development in pharmaceutical manufacturing.
• Chemical Synthesis: Utilized as a specialized building block in organic synthesis for constructing complex polycyclic molecules with potential biological activity.

Basic Information

Product Name	(7R)-8-Ethyl-7,8,9,10-Tetrahydro-1,6,7,8α,11-Pentahydroxy-5,12-Naphthacenedione
CAS No.	17514-35-1
Molecular Formula	C₂₀H₂₀O₇
Molecular Weight	372.37 g/mol
Synonyms	8-Ethyl-7,8,9,10-tetrahydro-1,6,7,8,11-pentahydroxy-5,12-naphthacenedione, (7R)-form; 7-Deoxy-13-dihydrodaunomycinone; 7R-8-Ethyl-7,8,9,10-tetrahydro-1,6,7,8α,11-pentahydroxy-5,12-naphthacenedione; 7-Deoxy-13-dihydrodaunorubicinone; Arugomycin B aglycone; Arugomycin B genin; (7R)-8-Ethyl-7,8,9,10-tetrahydro-1,6,7,8α,11-pentahydroxynaphthacene-5,12-dione
EINECS	Contact for details

Quality Control

Our (7R)-8-Ethyl-7,8,9,10-Tetrahydro-1,6,7,8α,11-Pentahydroxy-5,12-Naphthacenedione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.