Description

2,3,4,5-Tetrafluorobenzyl Nitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the nitrile group and the electronic effects imparted by the tetrafluoro substitution pattern on the benzene ring, enabling precise molecular construction. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved lipophilicity and target activity.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated liquid crystals and organic semiconductors, leveraging its structural rigidity and electronic properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic additions, and cyano-group transformations to introduce complex fluorinated segments.
• Research & Development: A valuable tool for academic and industrial R&D in exploring new fluorination strategies and structure-activity relationships.

Basic Information

Product Name	2,3,4,5-Tetrafluorobenzyl Nitrile
CAS No.	16582-93-7
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	(2,3,4,5-Tetrafluorophenyl)acetonitrile; 2,3,4,5-Tetrafluorobenzeneacetonitrile; Tetrafluorobenzyl Cyanide; α-Cyano-2,3,4,5-tetrafluorotoluene; 2,3,4,5-Tetrafluorobenzyl Cyanide; 2,3,4,5-Tetrafluorophenylethanenitrile; (Tetrafluorophenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrafluorobenzyl Nitrile is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.