Description

3-Iodo-4-Nitrobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring iodine, nitro, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling the formation of new carbon-carbon bonds.
• Chemical Derivatization: The nitro group can be selectively reduced to an amine, providing a handle for further functionalization to create diverse chemical libraries.

Basic Information

Product Name	3-Iodo-4-Nitrobenzotrifluoride
CAS No.	16499-53-9
Molecular Formula	C7H3F3INO2
Molecular Weight	316.99 g/mol
Synonyms	1-Iodo-2-nitro-5-(trifluoromethyl)benzene; 3-Iodo-4-nitro-α,α,α-trifluorotoluene; 4-Nitro-3-iodobenzotrifluoride; 2-Nitro-5-(trifluoromethyl)iodobenzene; Benzene, 1-iodo-2-nitro-5-(trifluoromethyl)-; α,α,α-Trifluoro-3-iodo-4-nitrotoluene
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-Nitrobenzotluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.