Description

(20R)-11β,17α,20,21-Tetrahydroxypregna-1,4-Dien-3-One CAS NO 15847-24-2 is a high-purity steroid derivative, specifically a tetrahydroxylated pregnadienone, valued for its role as a critical pharmaceutical intermediate and reference standard. Its precise stereochemistry and functional groups make it essential for advanced research and synthesis in regulated life science applications. This compound is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on steroid chemistry and drug development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex corticosteroid APIs and other bioactive steroid molecules.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing to ensure product identity and purity.
• Biochemical Research: Serves as a precursor or ligand in studies investigating steroid hormone receptors, metabolic pathways, and enzymatic activity.
• Process Development: Employed in scaling up and optimizing synthetic routes for steroid-based therapeutics in pilot plants and commercial production.
• Academic & Contract Research: Utilized in university laboratories and CROs for fundamental studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	(20R)-11β,17α,20,21-Tetrahydroxypregna-1,4-Dien-3-One
CAS No.	15847-24-2
Molecular Formula	C21H28O5
Molecular Weight	360.45 g/mol
Synonyms	11β,17α,20,21-Tetrahydroxypregna-1,4-dien-3-one; (20R)-11β,17α,20,21-Tetrahydroxypregna-1,4-dien-3-one; 11β,17α,20,21-Tetrahydroxypregna-1,4-dien-3-one, (20R)-; 11β,17α,20,21-Tetrahydroxy-1,4-pregnadien-3-one; 1,4-Pregnadiene-11β,17α,20,21-tetrol-3-one; Tetrahydroxypregnadienone
EINECS	Contact for details

Quality Control

Our (20R)-11β,17α,20,21-Tetrahydroxypregna-1,4-Dien-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and stored away from moisture and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.