Description

Dexamethasone 17-Propionate is a synthetic glucocorticoid ester derivative of dexamethasone. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, offering enhanced lipophilicity and potential for modified release profiles compared to the parent molecule. It is primarily utilized in advanced pharmaceutical research and development for creating novel corticosteroid formulations.

Application

• Pharmaceutical intermediate for the synthesis of novel corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research and development of topical formulations for dermatological conditions like eczema and psoriasis.
• Precursor in the development of depot or sustained-release injectable steroid therapies.
• Key starting material (KSM) for manufacturing specialized anti-inflammatory and immunosuppressive drugs.
• Reference standard in analytical laboratories for quality control and method development.
• Biochemical research tool for studying glucocorticoid receptor activity and metabolic pathways.

Basic Information

Item	Detail
Product Name	Dexamethasone 17-Propionate
CAS No.	15423-89-9
Molecular Formula	C24H33FO6
Molecular Weight	436.52 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-propionate; 17α-(1-Oxopropoxy)-9α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Dexamethasone 17-propanoate; Dexamethasone 17-propionic acid ester; NSC 39471
EINECS	Contact for details

Quality Control

Our Dexamethasone 17-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents is provided with every shipment. We can support development projects with material meeting pharmaceutical intermediate grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.