Description

9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate is a high-purity synthetic corticosteroid derivative, specifically a 17-valerate ester prodrug. This compound is valued for its potent anti-inflammatory and immunosuppressive pharmacological activity, serving as a critical advanced intermediate in the synthesis of modern topical and systemic steroid pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on developing next-generation dermatological and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs, such as fluticasone valerate and related analogues.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new glucocorticoid receptor agonists.
• Dermatological Drug Synthesis: Essential for manufacturing topical creams, ointments, and lotions designed to treat eczema, psoriasis, and dermatitis.
• Anti-inflammatory Agent Production: Serves as a precursor for drugs targeting inflammatory conditions like asthma, allergic rhinitis, and arthritis.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production for commercial pharmaceutical manufacturing.
• Reference Standard: Can be utilized as a chromatographic reference standard for quality control and analytical method development.

Basic Information

Product Name	9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate
CAS No.	15423-85-5
Molecular Formula	C27H37FO6
Molecular Weight	476.58 g/mol
Synonyms	Fluticasone 17-Valerate; Fluticasone Impurity F (Valerate Ester); 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate; 6α,9-Difluoro-11β,17-dihydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid pentyl ester (related); SQ 41,542 (historical code); NSC 113939; Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-valerate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide Certificates of Analysis (COA) with full traceability, ensuring compliance with cGMP guidelines for pharmaceutical intermediates. Specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider sealing under an inert gas such as nitrogen or argon in a moisture-proof environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.