Description

Betamethasone 17-Propionate 21-Mesylate is a synthetic corticosteroid ester prodrug, a key pharmaceutical intermediate in the synthesis of potent topical anti-inflammatory agents. Its primary commercial value lies in its role as a precursor for the manufacture of advanced dermatological and ophthalmic corticosteroid formulations. This high-purity intermediate is essential for pharmaceutical manufacturers and research institutions developing treatments for inflammatory skin conditions, allergies, and certain autoimmune disorders.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of Betamethasone Dipropionate and other high-potency corticosteroid APIs.
• Topical Corticosteroid Production: Used in manufacturing creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.
• Ophthalmic Formulation Development: Serves as a starting material for steroid preparations used to treat inflammatory eye conditions.
• Veterinary Pharmaceutical Synthesis: Employed in creating anti-inflammatory treatments for animals.
• Research & Development: Used in biochemical research to study glucocorticoid receptor activity and inflammatory pathways.
• Process Development & Scale-Up: Supports process chemistry for optimizing commercial manufacturing routes of corticosteroid drugs.

Basic Information

Product Name	Betamethasone 17-Propionate 21-Mesylate
CAS No.	15423-80-0
Molecular Formula	C26H37FO8S
Molecular Weight	528.63 g/mol
Synonyms	9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate 21-methanesulfonate; Betamethasone 17-propionate 21-mesilate; Betamethasone 17-propionate mesylate; NSC 39471; SQ 15102; Betamethasone propionate mesylate; 21-Mesylate of Betamethasone 17-propionate
EINECS	Contact for details

Quality Control

Our Betamethasone 17-Propionate 21-Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting purity, related substances, and residual solvents are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.