Description

Diphenhydramine Methiodide is a quaternary ammonium salt derivative of the antihistamine diphenhydramine. This compound is a crucial pharmacological reference standard and research chemical, primarily used to study cholinergic and histaminergic receptor interactions. It is essential for pharmaceutical R&D laboratories, academic research institutions, and chemical manufacturers engaged in neuropharmacology and medicinal chemistry.

Application

• Pharmacological Research: Acts as a muscarinic acetylcholine receptor (mAChR) antagonist for in vitro and ex vivo studies.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical compounds.
• Medicinal Chemistry: Serves as a key intermediate or precursor in the synthesis of more complex cholinergic agents for structure-activity relationship (SAR) studies.
• Biochemical Assays: Employed in receptor binding assays to investigate ligand-receptor interactions and signal transduction pathways.
• Academic & Educational Use: Utilized in university teaching labs for demonstrating principles of autonomic pharmacology.

Basic Information

Item	Details
Product Name	Diphenhydramine Methiodide
CAS No.	14177-81-2
Molecular Formula	C18H24INO
Molecular Weight	397.30 g/mol
Synonyms	Diphenhydramine Methyl Iodide; Benzhydramine Methiodide; 2-(Diphenylmethoxy)-N,N-dimethylethanaminium Methyl Iodide; N,N-Dimethyl-2-(diphenylmethoxy)ethanaminium Methyl Iodide; DPHM; NSC 113986; Diphenhydramine Quaternary Ammonium Salt
EINECS	Contact for details

Quality Control

Our Diphenhydramine Methiodide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.