Description

16α-Methyl-11β,17α,21-Trihydroxy-1,4,6-Pregnatriene-3,20-Dione is a synthetic corticosteroid derivative, a key intermediate in the production of potent anti-inflammatory and immunosuppressive pharmaceutical agents. Its precise molecular structure is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredients (APIs) derived from it. This high-purity intermediate is essential for manufacturers in the pharmaceutical and research sectors who require a reliable and consistent supply for the synthesis of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the multi-step synthesis of potent glucocorticoid drugs.
• Anti-inflammatory Drug Synthesis: Used in the manufacture of advanced corticosteroids for treating conditions like arthritis, asthma, and severe allergic reactions.
• Immunosuppressant Production: Serves as a precursor for APIs used in organ transplant rejection prevention and autoimmune disease management.
• Research & Development: Utilized in biochemical and pharmacological research to study steroid receptor activity and develop new therapeutic entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Product Name	16α-Methyl-11β,17α,21-Trihydroxy-1,4,6-Pregnatriene-3,20-Dione
CAS No.	13954-10-4
Molecular Formula	C₂₂H₂₈O₆
Molecular Weight	388.46 g/mol
Synonyms	16α-Methylprednisolone; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4,6-triene-3,20-dione; 16α-Methyl-δ1,4,6-pregnatriene-11β,17α,21-triol-3,20-dione; 16α-Methyl-11β,17α,21-trihydroxy-1,4,6-pregnatriene-3,20-dione; 16α-Methylprednisolone (Intermediate); 16α-Methyl-δ1,4,6-pregnatriene-11β,17α,21-triol-3,20-dione; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4,6-triene-3,20-dione
EINECS	Contact for details

Quality Control

Our 16α-Methyl-11β,17α,21-Trihydroxy-1,4,6-Pregnatriene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container is opened.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.