Description

11β,16α,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound is a key precursor in the synthesis of potent anti-inflammatory and immunosuppressive agents, valued for its defined stereochemistry and chemical structure. It is essential for research and development laboratories, as well as manufacturing facilities, producing advanced steroid-based active pharmaceutical ingredients (APIs) for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent glucocorticoid drugs, such as dexamethasone and betamethasone derivatives.
• Anti-inflammatory Drug Research: Used in R&D for developing novel corticosteroid therapies targeting inflammation, autoimmune disorders, and allergic conditions.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid APIs under Good Manufacturing Practice (GMP) guidelines.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding, metabolism, and the mechanism of action of steroid hormones.

Basic Information

Product Name	11β,16α,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
CAS No.	13951-70-7
Molecular Formula	C21H28O6
Molecular Weight	376.45 g/mol
Synonyms	9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-hydroxyprednisolone; 9α-Fluoro-16α-methylprednisolone intermediate; δ1-9α-Fluoro-16α-hydroxyprednisolone; 11β,16α,17,21-Tetrahydroxy-9α-fluoropregna-1,4-diene-3,20-dione; 16α-Hydroxy-9α-fluoroprednisolone; A key fluorinated prednisolone derivative.
EINECS	Contact for details

Quality Control

Our 11β,16α,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material aligned with customer-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants. Handle and store under an inert atmosphere to minimize the risk of oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.