Description

Deflazacort CAS NO 13649-88-2 is a synthetic glucocorticoid prodrug, a member of the oxazoline class of corticosteroids. It is valued for its potent anti-inflammatory and immunosuppressive properties, offering a therapeutic profile with a potentially reduced side effect burden compared to some other steroids. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing oral solid dosage forms, primarily for the treatment of inflammatory and autoimmune conditions such as Duchenne muscular dystrophy.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablet formulations for systemic corticosteroid therapy.
• Anti-inflammatory Medications: Manufacture of drugs targeting chronic inflammatory diseases, including certain types of arthritis and asthma.
• Immunosuppressive Therapy: Used in formulations for conditions where modulation of the immune system is required.
• Duchenne Muscular Dystrophy (DMD) Treatment: A key therapeutic agent in medications approved for delaying the progression of DMD.
• Research & Development: Serves as a reference standard and raw material in pharmaceutical R&D for novel corticosteroid delivery systems.
• Generic Drug Production: Critical for manufacturers producing bioequivalent versions of branded deflazacort medications.

Basic Information

Product Name	Deflazacort
CAS No.	13649-88-2
Molecular Formula	C25H31NO6
Molecular Weight	441.52 g/mol
Synonyms	Deflazacort; L-5458; Azacort; 11β,21-Dihydroxy-2'-methyl-5'βH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate; (11β,16β)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione; DL-458-IT; Oxazacort
EINECS	Contact for details

Quality Control

Our Deflazacort is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including HPLC assay, related substances profiling, and residual solvent analysis to ensure identity, purity, and safety. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting full compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.