Description

Hydrocortisone-17-Butyrate is a potent synthetic corticosteroid ester, specifically a 17α-butyrate derivative of hydrocortisone. This modification significantly enhances its topical anti-inflammatory and antipruritic activity while optimizing its dermal penetration and local bioavailability. It is a critical active pharmaceutical ingredient (API) for formulators developing high-efficacy dermatological treatments. Key industries requiring this compound include the pharmaceutical sector for topical creams and ointments, as well as advanced dermatological research and development.

Application

• Primary API in Topical Corticosteroid Formulations: Used as the key therapeutic agent in prescription-strength creams, ointments, lotions, and gels for treating severe inflammatory skin conditions.
• Treatment of Eczema and Dermatitis: Effective in managing symptoms of atopic dermatitis, contact dermatitis, and other eczematous disorders by reducing inflammation, redness, and itching.
• Psoriasis Therapy: Incorporated into treatments aimed at controlling plaque psoriasis by slowing skin cell turnover and reducing scaling and plaque formation.
• Specialized Dermatological Preparations: Serves as a base for compounding pharmacies to create customized potency formulations for specific patient needs.
• Veterinary Dermatology: Applied in topical treatments for inflammatory skin conditions in animals under veterinary supervision.
• Pharmaceutical Research & Development: Utilized as a reference standard and in preclinical studies for developing new topical drug delivery systems and evaluating anti-inflammatory efficacy.

Basic Information

Product Name	Hydrocortisone-17-Butyrate
CAS No.	13609-67-1
Molecular Formula	C25H36O6
Molecular Weight	432.55 g/mol
Synonyms	Hydrocortisone 17-Butyrate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate; Cortisol 17-butyrate; Prednicarbate related compound C (EP); HCB; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate; Locoid (brand name API); Hydrocortisone butyrate
EINECS	237-122-1

Quality Control

Our Hydrocortisone-17-Butyrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature between 15°C and 25°C (59°F and 77°F). The container should be kept in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.