Description

Hydrocortisone 17,21-Methyl Orthobutyrate is a synthetic corticosteroid derivative, specifically a methyl orthobutyrate ester of hydrocortisone. This compound is a crucial pharmaceutical intermediate, valued for its role in the synthesis of more potent and targeted steroid-based active pharmaceutical ingredients (APIs). It is primarily needed by manufacturers in the pharmaceutical and fine chemical industries for research, development, and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the multi-step synthesis of advanced corticosteroid APIs.
• Anti-inflammatory Drug Research: Used in R&D for developing novel topical and systemic anti-inflammatory agents.
• Steroid Prodrug Development: Serves as a precursor for prodrugs designed to improve bioavailability or targeting.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor activity and metabolic pathways.

Basic Information

Product Name	Hydrocortisone 17,21-Methyl Orthobutyrate
CAS No.	13609-63-7
Molecular Formula	C₂₆H₃₈O₇
Molecular Weight	462.58 g/mol
Synonyms	Hydrocortisone 17,21-Orthobutyrate Methyl Ester; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17,21-(Methyl Orthobutyrate); Cortisol 17,21-Methyl Orthobutyrate; 17,21-O-(1-Methoxyethylidene)-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; Hydrocortisone Methyl Orthobutyrate; Hydrocortisone 17,21-Acetonide Methyl Butyrate (related); NSC 113939
EINECS	Contact for details

Quality Control

Our Hydrocortisone 17,21-Methyl Orthobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards suitable for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.