Description

2-Nitro-4-(Trifluoromethyl)Phenylacetonitrile is a versatile aromatic nitrile building block characterized by its nitro and trifluoromethyl substituents. This compound is highly valued in advanced organic synthesis for its role as a key intermediate in the development of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the nitro and cyano groups serve as reactive handles for further functionalization.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, where the nitro group can influence color properties and lightfastness.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for constructing biaryl systems important in medicinal chemistry.

Basic Information

Item	Details
Product Name	2-Nitro-4-(Trifluoromethyl)Phenylacetonitrile
CAS No.	13544-06-4
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	2-Nitro-α-(trifluoromethyl)benzeneacetonitrile; (2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile; α-Cyano-2-nitro-α,α,α-trifluoro-p-xylene; 4-(Trifluoromethyl)-2-nitrobenzyl cyanide; 2-Nitro-4-trifluoromethylphenylacetonitrile; Benzeneacetonitrile, 2-nitro-α-(trifluoromethyl)-; p-(Trifluoromethyl)-o-nitrobenzyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Nitro-4-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.