Description

Bleomycin A5 is a potent glycopeptide antibiotic and a key component of the bleomycin family of antitumor agents. Its primary value lies in its ability to induce single-strand and double-strand breaks in DNA, making it a critical active pharmaceutical ingredient (API) for targeted chemotherapy. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing injectable chemotherapeutic formulations. The product is supplied under the identifier CAS NO 11116-32-8.

Application

Bleomycin A5 is a specialized pharmaceutical intermediate with targeted applications:

• Oncological Drug Manufacturing: As an active pharmaceutical ingredient (API) in injectable chemotherapy formulations for treating various cancers, including squamous cell carcinomas, lymphomas, and testicular cancers.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate mechanisms of DNA cleavage and develop novel cancer therapeutics.
• Reference Standard Production: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmacopeial testing (e.g., USP, EP).
• Biochemical Research: Employed as a tool compound in molecular biology to study DNA repair pathways and cellular responses to genotoxic stress.

Basic Information

Product Name	Bleomycin A5
CAS No.	11116-32-8
Molecular Formula	C55H84N17O21S2+
Molecular Weight	Approx. 1417.5 g/mol (as cation)
Synonyms	Bleomycin A5; Bleomycin A5 Hydrochloride; Bleomycin A5 HCl; Pingyangmycin; Bleomycin A5 (Pingyangmycin); ZL-59; Bleomycin A5 sulfate; Bleomycin A5; Bleomycin A5 Copper-Free; N1-[3-(Dimethylsulfonio)propyl]bleomycinamide
EINECS	Contact for details

Quality Control

Our Bleomycin A5 is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing to ensure identity, purity, and potency meet stringent specifications for pharmaceutical use. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) are available upon request, detailing compliance with relevant pharmacopeial standards (e.g., USP, EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
pH (in solution)	4.5 - 6.0
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Bacterial Endotoxins	< 1.0 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.