Description

Hydroxyzine Pamoate is a salt form of the first-generation antihistamine hydroxyzine, offering enhanced stability and formulation properties. This compound is a critical active pharmaceutical ingredient (API) primarily used in the manufacture of prescription medications for the management of anxiety, pruritus, and as a pre-operative sedative. It is essential for pharmaceutical companies and research institutions developing solid oral dosage forms, requiring a reliable supply of high-purity material. Hydroxyzine Pamoate CAS NO 10246-75-0 is supplied to meet the stringent demands of global pharmaceutical production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription anti-anxiety and antipruritic (anti-itch) medications.
• Generic Drug Manufacturing: Sourcing for the production of generic equivalents to branded hydroxyzine pamoate capsules and tablets.
• Pre-Formulation & Formulation Development: Used in R&D for studying solubility, stability, and compatibility in new drug delivery systems.
• Clinical Trial Material: Served as a key component in the manufacture of drugs for Phase I-III clinical studies.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for sedation and treatment of allergic conditions in animals.
• Reference Standard: Serves as a high-purity chemical standard for quality control and analytical testing in laboratories.

Basic Information

Product Name	Hydroxyzine Pamoate
CAS No.	10246-75-0
Molecular Formula	C21H27ClN2O2 • C23H16O6
Molecular Weight	763.27 g/mol
Synonyms	Hydroxyzine Pamoate; Hydroxyzine Embonate; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine pamoate salt; Atarax Pamoate; Vistaril (brand name salt form); (±)-Hydroxyzine pamoate; 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol compound with 4,4'-methylenebis[3-hydroxy-2-naphthoic acid]; Fumarate (common alternate salt)
EINECS	Contact for details

Quality Control

Our Hydroxyzine Pamoate is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality assurance protocols are designed to ensure batch-to-batch consistency, identity, purity, and strength. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, residual solvents, and heavy metals. Our commitment to quality supports compliance with cGMP and relevant pharmacopeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F). The container should be kept in a dry, well-ventilated area away from incompatible materials. For long-term storage, consider conditions that minimize exposure to humidity and temperature fluctuations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.