Description

Cortisone 21-Hemisuccinate is a key pharmaceutical intermediate and a derivative of the corticosteroid hormone cortisone. This compound is crucial for the synthesis of water-soluble prodrugs and other modified corticosteroids, enhancing bioavailability and formulation flexibility. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of injectable and topical anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing cortisone sodium succinate and other corticosteroid prodrugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of injectable corticosteroid formulations for rapid anti-inflammatory action.
• Research & Development: Serves as a standard and starting material in steroid chemistry research for novel drug discovery.
• Prodrug Synthesis: Its hemisuccinate ester group is utilized to create more soluble derivatives of parent steroid molecules.
• Biochemical Studies: Employed in laboratory studies to investigate glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	Cortisone 21-Hemisuccinate
CAS No.	10215-75-5
Molecular Formula	C25H32O8
Molecular Weight	460.52 g/mol
Synonyms	Cortisone 21-hemisuccinate; Cortisone hydrogen succinate; 21-Hemisuccinyloxy-17α-hydroxy-4-pregnene-3,11,20-trione; 4-Pregnene-17α,21-diol-3,11,20-trione 21-hemisuccinate; Cortisone 21-(hydrogen succinate); NSC 106965; Cortisone hemisuccinate
EINECS	233-544-5

Quality Control

Our Cortisone 21-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR spectroscopy, and control of specific impurities, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.