Description

n-[(20S)-20-(Dimethylamino)-16α-Hydroxy-4α-(Hydroxymethyl)-4,14-Dimethyl-9,19-Cyclo-5α-Pregn-6-En-3β-Yl]-n-Methylbenzamide is a high-purity, complex steroidal alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced intermediate or reference standard for the synthesis and study of novel therapeutic agents, particularly in the fields of oncology and endocrinology. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation steroid-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-derived active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new drug candidates targeting hormone receptors.
• Biochemical Research: Utilized in vitro and in vivo studies to investigate steroid biosynthesis pathways and related biological mechanisms.
• Process Development: Employed in the optimization and scale-up of synthetic routes for steroidal compounds under cGMP conditions.

Basic Information

Product Name	n-[(20S)-20-(Dimethylamino)-16α-Hydroxy-4α-(Hydroxymethyl)-4,14-Dimethyl-9,19-Cyclo-5α-Pregn-6-En-3β-Yl]-n-Methylbenzamide
CAS No.	10088-26-3
Molecular Formula	C33H50N2O3
Molecular Weight	522.77 g/mol
Synonyms	20-(Dimethylamino)-16α-hydroxy-4α-(hydroxymethyl)-4,14-dimethyl-9,19-cyclo-5α-pregn-6-en-3β-yl N-methylbenzamide; 16α-Hydroxy-20-dimethylamino-4α-hydroxymethyl-4,14-dimethyl-9,19-cyclo-5α-pregn-6-en-3β-yl N-methylbenzamide; Benzamide, N-[(20S)-20-(dimethylamino)-16α-hydroxy-4α-(hydroxymethyl)-4,14-dimethyl-9,19-cyclo-5α-pregn-6-en-3β-yl]-N-methyl-; Cyclopamine derivative; Steroidal benzamide alkaloid.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay purity and impurity profiles. Specifications can be aligned with research-grade or cGMP requirements based on customer needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.