Description

9-Bromo-6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of potent topical corticosteroids, offering significant value in medicinal chemistry research and development. It is primarily needed by pharmaceutical manufacturers and R&D laboratories focused on developing novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical corticosteroid APIs, such as Halobetasol Propionate and related analogues.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new steroid-based drugs with optimized potency and reduced side effects.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Development: Employed in scaling up and optimizing synthetic routes for corticosteroid production under cGMP conditions.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding and the mechanisms of anti-inflammatory action.

Basic Information

Product Name	9-Bromo-6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	1997-73-5
Molecular Formula	C₂₅H₃₂BrFO₆
Molecular Weight	527.43 g/mol
Synonyms	9-Bromo-6α-Fluoro-11β,17,21-Trihydroxy-16α-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate; 9-Bromo-6α-Fluoro-16α-Methylprednisolone 21-Acetate; Halobetasol Propionate Intermediate; 9-Bromo-6α-Fluoro-11β,17,21-Trihydroxy-16α-Methyl-1,4-Pregnadiene-3,20-Dione 21-Acetate; 9-Bromo-6-Fluoro-11β,17,21-Trihydroxy-16α-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate; U-82247; 9-Bromo-6α-Fluoro-16α-Methylprednisolone Acetate
EINECS	Contact for details

Quality Control

Our 9-Bromo-6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with stringent specifications suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.