Description

Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Alpha)- is a high-purity synthetic corticosteroid derivative, specifically a phosphorylated prodrug of a potent glucocorticoid. This compound is of significant value in pharmaceutical research and development due to its targeted mechanism of action and enhanced solubility profile. It is primarily required by advanced pharmaceutical manufacturers and research institutions engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the manufacture of potent topical and systemic corticosteroid APIs (Active Pharmaceutical Ingredients).
• Prodrug Development: Serves as a model compound in research for designing phosphorylated prodrugs to improve drug delivery and bioavailability.
• Anti-inflammatory Research: Used in preclinical and clinical research studies to investigate mechanisms of glucocorticoid receptor-mediated anti-inflammatory effects.
• Immunosuppressive Agent Synthesis: A critical building block for synthesizing advanced immunosuppressive medications used in organ transplantation and autoimmune diseases.
• Dermatological Formulations: Employed in the development of high-potency creams and ointments for treating severe skin conditions like psoriasis and eczema.
• Biochemical Research: Utilized as a tool compound in molecular biology to study steroid hormone action and gene expression regulation.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Alpha)-
CAS No.	1997-15-5
Molecular Formula	C27H33FO11P • 2Na
Molecular Weight	Contact for details
Synonyms	Disodium Phosphate Betamethasone Acetonide; Betamethasone 21-Phosphate Disodium Salt Acetonide; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(dihydrogen phosphate) disodium salt; Betamethasone Acetonide 21-Phosphate Disodium; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(dihydrogen phosphate) disodium salt; Betamethasone Phosphate Acetonide Disodium; A derivative of Betamethasone 17,21-dipropionate.
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and control of related substances and residual solvents. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or cGMP (current Good Manufacturing Practice) requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.