Description

3,4-Bis(Trifluoromethyl)Nitrobenzene is a high-value fluorinated aromatic intermediate characterized by its unique combination of nitro and trifluoromethyl functional groups. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the introduction of fluorine atoms is key to modulating properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoromethyl groups contribute to improved biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing thermal stability and optical properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart chemical resistance, low surface energy, and improved durability.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions and nucleophilic aromatic substitutions to introduce fluorinated aromatic rings into complex molecules.
• Dye & Pigment Intermediate: Employed in the production of specialized fluorinated dyes with unique color fastness and solubility properties.

Basic Information

Product Name	3,4-Bis(Trifluoromethyl)Nitrobenzene
CAS No.	1978-20-7
Molecular Formula	C8H3F6NO2
Molecular Weight	259.11 g/mol
Synonyms	1-Nitro-3,4-bis(trifluoromethyl)benzene; 3,4-Bis(trifluoromethyl)-1-nitrobenzene; Nitro-3,4-bis(trifluoromethyl)benzene; 3,4-Di(trifluoromethyl)nitrobenzene; Benzene, 1-nitro-3,4-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-4-nitroxylene; NSC 404058
EINECS	217-848-6

Quality Control

Our 3,4-Bis(Trifluoromethyl)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.